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Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease.
Clinical Chemistry & Laboratory Medicine. 46(3):387-392, March 2008.
Zinellu, Angelo 1,2,*; Pinna, Antonio 3; Sotgia, Salvatore 1,2; Zinellu, Elisabetta 4; Usai, Maria Franca 1; Carta, Francesco 3; Gaspa, Leonardo 1,2; Deiana, Luca 1; Carru, Ciriaco 1,2,*
Background: We investigated the levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), as well as homocysteine and cysteine thiols, in a cohort of subjects affected by retinal vein occlusion (RVO) disease.
Methods: Capillary electrophoresis analysis was performed in both RVO subjects (ns54) and in a control group (n s 32).
Results: No differences were found between controls and patients; however, after categorisation for RVO type, central RVO (CRVO) patients showed higher levels of ADMA (0.710 +/- 0.139 [mu]mol/L) than controls (0.635 +/- 0.117 [mu]mol/L) and branch RVO patients (0.642 +/- 0.096 [mu]mol/L). Moreover, cysteine plasma levels were also significantly higher in CRVO patients than in controls (265.8 +/- 46.9 vs. 226.7 +/- 51.9 [mu]mol/L, p-0.01), while homocysteine plasma concentration was more or less identical in all groups.
Conclusions: We hypothesise that the elevated levels of cysteine in CRVO patients may post-translationally inhibit dimethylarginine dimethylaminohydrolase enzyme activity, as already described for homocysteine, thus contributing to the accumulation of ADMA in this patient group.
Copyright (C) 2008 Walter de Gruyter